个人简介

师从周良辅院士和吴劲松教授，主要从事脑胶质瘤、脑膜瘤、转移癌、神经鞘瘤等各类脑肿瘤的手术治疗，尤其擅长语言区、运动区、岛叶、基底节、丘脑等功能区和深部脑肿瘤的微创显微外科手术，对唤醒手术和运动语言等功能保护具有丰富经验，曾获得第六届全国胶质瘤手术比赛冠军、中国脑机接口“华瑙奖”杰出青年奖。科研上主要致力于植入式脑机接口帮助功能障碍患者重建功能和大脑语言等高级认知功能的神经机制研究，相关工作在Nature、Nature Human Behaviour、Nature Communications、Science Advances、Brain、Journal of Neurosurgery等高影响力杂志发表。

研究方向和临床专长

路俊锋医生的临床专长是采用各类先进的脑功能定位技术（包括唤醒手术、脑功能成像，术中电生理，术中磁共振，术中皮层脑电图）进行运动、语言的功能保护，从而最大程度安全切除脑肿瘤或病灶并控制癫痫等症状。

路俊锋医生的研究兴趣是利用术中电生理技术（术中直接电刺激、高密度ECoG、人脑单神经元记录技术）探索大脑如何加工语言，如何产生和感知汉语语言，进而明确大脑的关键功能区从而实现患者的语言功能精准保护。同时，路俊锋博士还致力于汉语语言脑机接口研究，帮助言语障碍的患者恢复语言表达能力。

代表性成果

针对植入式汉语脑机接口面临的瓶颈，围绕汉语语言的“神经机制解析-解码技术开发-临床试验转化”开展了系统研究：

1. 通过高时空分辨率植入式脑机接口解析汉语声调“感知-生成-理解”的神经编码机制，为汉语语言BCI提供了理论基础（Nat Hum Behav.2022;Nat Commun.2021,2023;Brain 2021）
2. 开发神经科学驱动下的汉语语言解码算法，实现语句级神经特征解码和语音合成（Sci Adv.2023; Cell Rep. 2024; STAR Protoc. 2025）
3. 基于上述理论机制和技术方法，联合中科院脑智卓越中心开展国内首个无线侵入式脑机接口临床试验（截肢患者实现对光标的自由控制，标志着中国在侵入式脑机接口技术上成为继美国之后，全球第二个进入临床试验阶段的国家）；这项工作得Nature官网、人民日报、新华社、央视等媒体报道。

代表性论著

1. Zhou, Y.#, Yan, P.#, Zhao, Z.#, Zhang, J., Lu, J.* (2025). Increased Risk of Permanent Speech Production Deficits Following Resection of the Dominant Ventral Precentral Gyrus Compared With Broca’s Area, Operative Neurosurgery, 00:1-11.
2. Bhaya-Grossman, I., Leonard, M.K., Zhang Y., Gwilliams, L., Johnson, K., Lu, J., Chang, E.F.*(2025). Shared and language-specific phonological processing in the human temporal lobe, Nature, DOI: https://doi.org/10.1038/s41586-025-09748-8
3. Zhang, D., Wang, Z., Qian, Y., Zhao, Z., Liu, Y., Lu, J., Li, Y. (2025). Protocol to perform offline ECoG brain-to-text decoding for natural tonal sentences, STAR Protocols, Volume 6, Issue 1, 103650
4. Zhang, D.#, Wang, Z.#, Qian, Y.#, Zhao, Z., Liu, Y., Hao, X., Li, W., Lu, S., Zhu, H., Chen, L., Xu, K., Li, Y., Lu, J. (2024). A brain-to-text framework for decoding natural tonal sentences, Cell Reports, Volume 43, Issue 11.
5. Lu, J.#, Li, Y.#, Zhao, Z.#, Liu, Y., Zhu, Y., Mao, Y., Wu, J. & Chang, E. F. *(2023). Neural control of lexical tone production in human laryngeal motor cortex, Nature Communications, 14(1), 6917.
6. Liu, Y.#, Zhao, Z.#, Xu, M.#, Yu, H., Zhu, Y., Zhang, J., Bu, L., Zhang, X., Lu, J., Li, Y., Ming, D., & Wu, J.* (2023). Decoding and synthesizing tonal language speech from brain activity, Science Advances, 9(23), eadh0478.
7. Zhao, Z.#, Huang, C.#, Yuan, S.#, Zhang, J., Lin, C., Lu, J.*, Duffau, H., & Wu, J. (2023). Convergence of the arcuate fasciculus and third branch of the superior longitudinal fasciculus with direct cortical stimulation-induced speech arrest area in the anterior ventral precentral gyrus, Journal of Neurosurgery, 1(aop), 1-12.（封面文章）
8. Zhu, Y.#, Xu, M.#, Lu, J.#, Hu, J.#, Kwok, VPY., Zhou, Y., Yuan, D., Wu, B., Zhang, J., Wu, J., Tan, L.H.(2022). Distinct spatiotemporal patterns of syntactic and semantic processing in human inferior frontal gyrus, Nature Human Behaviour, 6, 1104–1111.
9. Zhou, Y.#, Zhao, Z.#,Zhang, J., NUF Hameed, Zhu, F., Feng, R., Zhang, X., Lu, J.*, Wu, J.(2022). Electrical stimulation-induced speech-related negative motor responses in the lateral frontal cortex, Journal of Neurosurgery, 137(2): 496-504
10. Li, Y.#, Tang, C.#, Lu, J.#, Wu, J., Chang, E.(2021). Human cortical encoding of pitch in tonal and non-tonal languages. Nature Communications, 12, 1161, 1-12
11. NUF, H.#, Zhao, Z.#, Zhang, J., Bu, L, Zhou, Y., Jin, L., Bai, H., Li, W., Tang, J., Lu, J.*(2021). Wu, J., Mao, Y. A novel intra-operative brain mapping integrated task-presentation platform, Operative Neurosurgery. 20(5),477-483
12. Lu, J.#, Zhao, Z.#, Zhang, J., Wu, B., Zhu, Y., Chang, E., Wu, J.*, Duffau, H., Berger, M.S.(2021). Functional maps of direct electrical stimulation-induced speech arrest and anomia: a multicenter retrospective study, Brain, 144(8): 2541-2553 （编辑推荐文章）
13. Zhao, Z.#, Liu, Y.#, Zhang, J., Lu, J.*, Wu, J.(2021). Where is the speech production area? Evidence from direct cortical electrical stimulation mapping, Brain, 144(7): e61.